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The UK stock market ended the day nearly 1% lower at 7,073 after Europe introduced tougher curbs on UK travellers as part of ongoing efforts to fight the pandemic.
The new restrictions put pressure on airline stocks with EasyJet and Jet2 falling by around 5% each.
Luxury goods group Burberry fell 8.7% on the news Marco Gobbetti plans to step down as CEO and leave the company at the end of 2021.
Burberry said Gobbetti, who has led the transformation of the company's brand and business, wants to take up another opportunity that will enable him to return to Italy and be closer to his family.
Covid-19 vaccine maker AstraZeneca gained 2% after its Forxiga chronic kidney disease treatment was recommended for approval in the European Union. Separately, the pharmaceutical giant flagged positive trial results for its Nirsevimab passive immunisation against respiratory syncytial virus in infants.
Food-on-the-go retailer Greggs rallied 2.9% after serving up news of continued strong recovery in performance. The value sandwiches-to-sausage rolls seller said like-for-like sales in company-managed shops in recent weeks has remained positive versus the comparable period in 2019.
Greggs insisted this level of sustained sales recovery is 'stronger than we had anticipated' and if it were to continue, would have a 'materially positive impact on the expected financial result for the year'.
Elsewhere, outsourcer Serco improved 0.8% to 132.5p on news it has won a contract rebid worth up to £322 million from the UK's Department of Health and Social Care to continue providing support services to Covid-19 test centres.
CEO Rupert Soames said 'we are proud of the part we have played in building and operating the UK's highly successful Covid-19 testing infrastructure.
'From a standing start in March 2020, NHS Test & Trace has grown a network of regional, local and mobile sites which have delivered over 18.5 million individual tests, an average of 51,000 tests a day.'
Soames added that he is 'delighted that the DHSC has selected us to continue to support them in providing these services for at least the next 12 months'.
HgCapital Trust rose 3.4% to 349.5p after the private equity investor agreed the sale of workforce and people management software-as-a-service provider Allocate to RLDatix.
The deal values HGCapital's investment in Allocate at roughly £53.5 million, an uplift of £9.4 million or 21% over the carrying value of £44.1 million in the trust's net asset value as of 31 March 2021.
Engineering play Wood Group lost 2.2%, having agreed to pay compensation and other penalties of a combined $177 million related to bribery and corruption allegations related to historical conduct in its legacy Amec Foster Wheeler business.
Totally ticked up 3.8% to 39.7p after winning a contract worth up to £850,000 to provide endoscopy procedures to The Saolta Group of Hospitals in Galway, Ireland, covering six hospitals.
Brain health-focused Cambridge Cognition jumped 21.5% to 167p on its selection as the cognitive assessment partner for a large at-home study in a contract worth £2.2 million.